192 British Journal of Anaesthesia

Pulmonary artery catheterization in anaesthesia and intensive care.

Since its introduction nearly 30 yr ago, the pulmonary artery catheter (PAC) has become part of everyday management in cardiology, anaesthesia and intensive care but remains controversial. 37 78 136 164 The apparent failure to demonstrate improvements in patient outcome 66 68 192 and the risks associated with its use 153 have long been criticized. Failure to explore its full use and redundancy ...

A national survey of the impact of NAP4 on airway management practice in United Kingdom hospitals: closing the safety gap in anaesthesia, intensive care and the emergency department.

BACKGROUND The 4th National Audit Project of the Royal College of Anaesthetists' and Difficult Airway Society (NAP4) made recommendations to improve reliability and safety of airway management in hospitals. This survey examines its impact. METHODS A survey was sent to all UK National Health Service hospitals to examine changes in practice in response to NAP4. We performed a 'gap analysis' to ...

An open study of ropivacaine in extradural anaesthesia.

Ropivacaine 0.5%, 0.75% and 1.0% was investigated in an open study of extradural anaesthesia in three groups of 15 patients undergoing urological or orthopaedic surgery. Following a test dose of 3 ml of 1.0% lignocaine with 1:200,000 adrenaline, ropivacaine 20 ml was given in incremental doses over 4 min via a lumbar extradural catheter. The onset time for analgesia was short in all groups: T12...

Pharmacokinetics of midazolam given as an intranasal spray to adult surgical patients.

The aim of this study was to determine the bioavailability and absorption kinetics of midazolam given as an intranasal (i.n.) spray. In addition, plasma concentrations of the active metabolite, 1-hydroxymidazolam, were measured to give an indication of enteral absorption. An i.v. and i.n. midazolam dose were given in a crossover study to 14 adult surgical patients. Individual uptake profiles of...

Effects of rocuronium and vecuronium on intracranial pressure, mean arterial pressure and heart rate in neurosurgical patients.

We have evaluated the effects of a single bolus dose of rocuronium 0.6 mg kg-1 (group 1, n = 10) or vecuronium 0.1 mg kg-1 (group 2, n = 10) on intracranial pressure (ICP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP) and heart rate (HR) in 20 neurosurgical patients undergoing mechanical ventilation of the lungs during continuous sedation with sufentanil and midazolam. Before...

Planetary Health as a Central Context to the Sustainable Development Goals (SDGs)